Sleep Support

Zylaria®, or Xylaria nigripes, is a type of mushroom that was first used medicinally centuries ago in Traditional Chinese Medicine (TCM) practices. Like many mushrooms, it grows underground, about a foot down, in dark, damp and warm conditions but unusually, only where there’s also a termite nest, specifically, the nest of the Odontotermesformosanus termite.

Zylaria® is a rich source of amino acids, and not just for termites, but for us humans too. And the most exciting amino acid in this medical mushroom is gamma-aminobutyric acid or GABA.

• Proven to help reset the natural body clock
• Improved sleep patterns
• Increase restorative and peaceful sleep
• less time to fall asleep
• Stay asleep for longer
• Counteract the compounds that exhibit ‘excitement’ in our brain, helping the human body to unwind, relax, and feel at ease
• Synergistic effect with PharmaGABA

Xylaria nigripes

affron is an all-natural, premium saffron extract (Crocus sativus L.), which has been recognized by various international awards as the most clinically validated branded saffron extract worldwide. It is backed by eight human clinical studies that demonstrate its capacity to help improve mood, relieve symptoms associated with stress and occasional sadness, support relaxation, help enhance sleepiness, and improve mood in menopausal women. This clean-label saffron extract counts on proven bioavailability and rapid one-hour absorption.

• Increased levels of melatonin
• Improved primary outcome measures of sleep quality ratings
• affron supplementation was well-tolerated with no reported significant adverse effects or sluggishness, offering a natural support that avoids the effects of other botanicals or concentrated melatonin supplements that could promote daytime tiredness or sleepiness in some people

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial

GABA (gamma-aminobutyric acid) is naturally occurring amino acid in our brain. It is one of the major inhibitory neurotransmitters in the central nervous system and has been found in several peripheral tissues. Amino acid neurotransmitters are critical for the function of the central nervous system (CNS)

PharmaGABA® is a natural form of GABA manufactured by a fermentation process using a Lactobacillus bacteria – the same kind of bacteria used to ferment vegetables, cheese, wine and other traditional diets. The bacteria are fed nutrients, including glutamic acid from sugar cane, to produce a high level of GABA that can then be concentrated through a filtration process.

• Fall asleep more quickly and easily, and more rapidly moved to a state of deep sleep.
• Greater length of valuable non-REM sleep.
• Upon awakening subjects consistently reported a qualitatively better and more satisfying sleep experience.

Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans

PharmaGABA: A Breakthrough Study May Elevate a Natural Nutritive to the Status of Lifesaver

ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* HSP70 protects cells from cytotoxicity induced by TNF, monocytes, and oxidative stress.

HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant. Cytokines modulate or alter the immune system response. Cytokines are small and membrane-bound protein-based cell signaling molecules that aid cell-to-cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection, and trauma. Unfortunately, the heat shock response to stressors of all kinds decreases with age. Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS per day. (The commercially available form of ETAS is 50% elemental ETAS, requiring a dosage of 200 mg per day.)

Double-blind, placebo-controlled research has shown ETAS effectively:
• Increases quality of sleep
• Alleviates occasional stress by improving heart rate variability
• Stay asleep for longer
• Raises cognitive performance, reduces fatigue, and improves the stress response
• Improves sleep-related-stress physiological indices

Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals

ETAS™ Clinical Evidence

UltraMag™ Magnesium stack is a highly bioavailable sucrosomial complex of magnesium oxide providing 32 percent elemental magnesium. Because the magnesium is covered by a phospholipids plus sucrose esters of fatty acids matrix, its absorption is not impacted by the presence of other nutrients, unlike conventional forms of magnesium. A head-to-head test demonstrated that Sucrosomial Magnesium had faster absorption and 20 percent higher bioavailability than magnesium citrate, one of the most bioavailable forms of magnesium on the market.
Studies have shown that exercising without sufficient magnesium will lead to increased oxygen consumption and heart rate.

• Essential for production and storage of energy
• Supports proper function of nerves and muscles
• Helps the development of strong bones
• Improves muscle performance
• Lower lactate levels in your blood. Lactate (lactic acid) is a metabolite that is primarily produced by intense physical exercise
• Plays a major role in strengthening your immune system. It works similarly to an antioxidant by strengthening your defenses and protecting you from diseases.

Magnesium bioavailability after administration of sucrosomial® magnesium: results of an ex-vivo study and a comparative, double-blinded, cross-over study in healthy subjects

Therapeutic Uses of Magnesium

New experimental and clinical data on the relationship between magnesium and sport

L-theanine is an amino acid found primarily in green and black tea and some mushrooms. It’s said to help ease anxiety, stress, and reduce insomnia.

It is a well-known agent for improving sleep disturbances. It is structurally similar to the excitatory neurotransmitter glutamate in the brain and possibly blocks glutamate receptors in the central nervous system. It is commonly used to treat sleep disturbance, improve non-rapid eye movement (NREM) sleep, and reduce psychological stress. Early animal models suggest L-Theanine may have a neuro protective effect.

Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

Osmanthus fragrans is a powerful botanical harnessing a number of key antioxidants that are helpful for promoting a number of brain health benefits.

• Potential to support acetylcholine levels, the primary neurotransmitter in the human nervous system, by possibly decreasing its breakdown and increasing its synthesis in the human brain.
• Antioxidant, Anti-inflammatory, Sedative, Relaxant, Antispasmodic
• Neuroprotection and free radical scavenging effects

Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts