First Response

Magnesium L-Threonate is a mineral chelating agent that may allow the elemental magnesium to cross the blood-brain barrier. Research showed Magnesium L-Threonate is able to deliver magnesium to the brain and support memory / overall cognitive function. Magnesium L-Threonate may support healthy sleep habits.

Magnesium, especially magnesium L-threonate, can significantly enhance the density and plasticity of synapses as well as prevent memory decline. Magnesium plays a critical role in learning and memory by increasing the durability of synapses and enabling the brain to make new connections. Oral magnesium replacement decreases symptoms acutely following a concussion.

A randomized cohort study of the efficacy of PO magnesium in the treatment of acute concussions in adolescents

A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults

Pterostilbene, a nutrient from the same family as resveratrol, is an antioxidant and anti-inflammatory with preventive properties. It has shown to be many times more bioavailable than resveratrol and is easily transported into cells.

Pterostilbene has two to four times better cellular uptake than resveratrol and stays present in the body longer before it is eliminated. It is thought to be a potent sirtuin activating compound. Sirtuins play many roles across a broad spectrum of biological processes, including those that have a part in age related degenerative diseases. Pterostilbene specifically helps to activate SIRT 1 which has influence over DNA proteins. SIRT1 also works to support DNA repair and its many other cell protecting activities.

Pterostilbene exhibited a neuroprotective effect against cerebral ischemia in rats via anti-inflammatory mechanism.

One study demonstrated that pterostilbene reduced neuronal cell death, brain edema, improved brain architecture, and exerted anti-oxidant effects by reducing ROS and regulating Nrf2 and HO-1 signals. Furthermore, pterostilbene regulated NF-κB signaling and the PI3K/Akt/mTOR-JNK pathway. These observations propose pterostilbene as a potential therapeutic compound that could be explored further in the treatment of neonatal HI brain injury.

Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK–Akt/mTOR signaling in ischemic brain injury in neonatal rats

Neuroprotective and Anti-Inflammatory Effect of Pterostilbene Against Cerebral Ischemia/Reperfusion Injury via Suppression of COX-2

Coffee fruit, also known as coffee cherry or coffee berry, is a small, round stone fruit produced by the coffee plant. It is about the size of a grape and grows in bunches on the coffee plant. When raw, it is green in color and turns into a deep red, reddish-purple, or yellowish-red color as it ripens.

The coffee bean lies within the pit of the stone fruit. Raw coffee beans are extracted from the fruit for processing and roasting to make coffee, while the fruit is discarded.
Studies have shown that the coffee berry has numerous health effects, from increasing brain function to boosting immunity.

The coffee fruit is considered to be a superfood because it is rich in the following nutrients:
• Vitamin B2 (riboflavin)
• Magnesium
• Antioxidants
• Chlorogenic acid
• Quinic acid
• Diterpenes (cafestol and kahweol)

Coffee fruit is rich in antioxidants and polyphenols. Coffee berries are filled with antioxidants and polyphenols, such as chlorogenic acid. They protect your body from free radical damage, which can cause oxidative damage to cells and result in diseases.

Coffee fruit can protect your brain. Studies have shown that coffee fruit helps protect your brain from Alzheimer’s disease, dementia, and other age-related diseases. The protective effects of coffee berries is because of the procyanidins or polyphenols. Coffee fruit raises your levels of brain-derived neurotrophic factor (BDNF), which is a protein that protects your brain cells from damage and improves brain function. Clinical trials demonstrated a significant improvement in cognition, with concomitant observed changes in neurofunctional brain networks after a single 100 mg, it appears to increase exosomal BDNF, an essential neuroprotein.

Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults with Subjective Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study

Acute Cognitive Performance and Mood Effects of Coffeeberry Extract: A Randomized, Double Blind, Placebo-Controlled Crossover Study in Healthy Humans

B Vitamins are our energy sources and help to rebuild cells. Antioxidant vitamins such as vitamin C, D and E are also being studied for their effectiveness in concussion recovery. Antioxidants reduce or delay cell destruction which may prove useful as the body repairs itself.

Vitamin B12 enhances nerve repair and improves functional recovery after TBI by inhibiting ER stress-induced neuro injury.

Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury

Corrigendum: Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury

The impact of riboflavin on the duration of sport-related concussion: A randomized placebo-controlled trial

Brain Trauma and the Secondary Cascade in Humans: Review of the Potential Role of Vitamins in Reparative Processes and Functional Outcome

Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel.

The effect of Vitamins C and E on clinical outcomes of patients with severe traumatic brain injury: A propensity score matching study